Sometimes during a farming session I like to relax with a spot of fishing, even in dangerous places like Nightshade Pass. Although only dangerous to new players like me.
I can't say that I notice any difference in quality or number of catches. As long as you fish the bubbles you have about a 1 in 5 chance of catching something. My fishing level is about 50ish. But by next week it should be well into the 60ish